Genetic risk for T1D is conferred by over 100 genome-wide-significant regions, most of which impact T1D development by biological mechanisms yet to be determined. We have characterized the genetics of Network for Pancreatic Organ donors with Diabetes (nPOD) donors and living subjects with T1D in order to facilitate the discovery of novel genotype:phenotype associations.
Publications
Melanie R. Shapiro, Erin M. Tallon, Matthew E Brown, A. Posgai, Mark A Clements, Todd M. Brusko
Diabetologia, 2024
A genomic data archive from the Network for Pancreatic Organ donors with Diabetes
Daniel J Perry, Melanie R. Shapiro, Sonya W Chamberlain, I. Kusmartseva, S. Chamala, L. Balzano-Nogueira, Mingder Yang, J. Brant, Maigan A. Brusko, MacKenzie D Williams, Kieran M Mcgrail, James A. McNichols, Leeana D. Peters, A. Posgai, J. Kaddis, C. Mathews, C. Wasserfall, B. Webb-Robertson, M. Campbell-Thompson, D. Schatz, C. Evans-Molina, A. Pugliese, P. Concannon, Mark S. Anderson, M. German, C. Chamberlain, Mark A. Atkinson, T. Brusko
Scientific Data, 2023
Human immune phenotyping reveals accelerated aging in type 1 diabetes
Melanie R. Shapiro, Xiaoru Dong, Daniel J. Perry, James M. McNichols, P. Thirawatananond, A. Posgai, Leeana D. Peters, K. Motwani, Richard S. Musca, Andrew Muir, Patrick Concannon, Laura M. Jacobsen, Clayton E. Mathews, C. Wasserfall, Michael J. Haller, D. Schatz, Mark A. Atkinson, Maigan A. Brusko, Rhonda L. Bacher, T. Brusko
JCI Insight, 2023
De‐coding genetic risk variants in type 1 diabetes
Melanie R. Shapiro, P. Thirawatananond, Leeana D. Peters, Robert C. Sharp, S. Ogundare, A. Posgai, Daniel J Perry, T. Brusko
Immunology and Cell Biology, 2021