Melanie Shapiro laboratory

Genetics of Type 1 Diabetes Development and Immunotherapy Response

An anti-CRF antibody suppresses the HPA axis and reverses stress-induced phenotypes


Journal article


Hunter S. Futch, Karen N. McFarland, Brenda D. Moore, M. Zino Kuhn, B. Giasson, Thomas Ladd, Karen A. Scott, Melanie R. Shapiro, Rachel L. Nosacka, Marshall S. Goodwin, Yong Ran, Pedro E. Cruz, Daniel H. Ryu, Cara L. Croft, Yona Levites, C. Janus, Paramita Chakrabarty, Andrew R. Judge, T. Brusko, A. D. de Kloet, E. Krause, T. Golde
Journal of Experimental Medicine, 2019

Semantic Scholar DOI PubMedCentral PubMed
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APA   Click to copy
Futch, H. S., McFarland, K. N., Moore, B. D., Kuhn, M. Z., Giasson, B., Ladd, T., … Golde, T. (2019). An anti-CRF antibody suppresses the HPA axis and reverses stress-induced phenotypes. Journal of Experimental Medicine.


Chicago/Turabian   Click to copy
Futch, Hunter S., Karen N. McFarland, Brenda D. Moore, M. Zino Kuhn, B. Giasson, Thomas Ladd, Karen A. Scott, et al. “An Anti-CRF Antibody Suppresses the HPA Axis and Reverses Stress-Induced Phenotypes.” Journal of Experimental Medicine (2019).


MLA   Click to copy
Futch, Hunter S., et al. “An Anti-CRF Antibody Suppresses the HPA Axis and Reverses Stress-Induced Phenotypes.” Journal of Experimental Medicine, 2019.


BibTeX   Click to copy

@article{hunter2019a,
  title = {An anti-CRF antibody suppresses the HPA axis and reverses stress-induced phenotypes},
  year = {2019},
  journal = {Journal of Experimental Medicine},
  author = {Futch, Hunter S. and McFarland, Karen N. and Moore, Brenda D. and Kuhn, M. Zino and Giasson, B. and Ladd, Thomas and Scott, Karen A. and Shapiro, Melanie R. and Nosacka, Rachel L. and Goodwin, Marshall S. and Ran, Yong and Cruz, Pedro E. and Ryu, Daniel H. and Croft, Cara L. and Levites, Yona and Janus, C. and Chakrabarty, Paramita and Judge, Andrew R. and Brusko, T. and de Kloet, A. D. and Krause, E. and Golde, T.}
}

Abstract

A high-affinity monoclonal antibody (CTRND05) targeting corticotropin-releasing factor (CRF) blocks stress-induced corticosterone increases, counteracts effects of chronic variable stress, and induces other phenotypes consistent with suppression of the HPA axis.


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